On Saturday, the Cobras made up the snowed-out game with Marcellus, who lost its opener to Solvay 57-44.
But the Mustangs recovered in a big way against Grimes, controlling things most of the way and giving the hosts a 55-47 defeat.
Behind 16-6 after one period, Grimes saw the deficit continue to grow in the face of a deep, balanced Marcellus attack. Eventually, the margin grew to 49-25 before th4e Cobras made a series of late shots to move back within sight.
Vaught and Godlewski each had eight points, while Guhin and Shattuck managed seven points apiece. Marcellus saw Bethanie Abbott lead both sides with 13 points.
After a week to rest, Grimes is home again Friday to meet Solvay.