It's the third straight year Ludden has faced Adirondack in the playoffs. In 2007, the Gaelic Knights prevailed in a 35-28 semifinal classic on its way to the state title, and Ludden survived a 24-14 decision in last year's opening round.
As this went on, Jordan-Elbridge went into crossover play and took a 30-20 loss to Cato-Meridian.
The Eagles gained a 13-8 halftime lead, as Jeff Guadagnolo scored on an eight-yard run in the first period and Mike Killeen added a 12-yard scoring run in the second quarter.
But the Blue Devils would come back behind Nick LaLone and Joe Gray, each of whom would score twice as Cato grabbed a 22-13 lead early in the fourth quarter.
J-E pulled within two on Zach Frost's 47-yard TD pass to Preston Bishop and Liam Corfield's extra point, but LaLone answered by going 60 yards to Gray for the clinching touchdown late in regulation.