Raphael Gonzalez Martinez, 31, of Bowman, S.C. was charged with one count of felony driving under the influence involving a death, in the wrong-way crash that killed 14-year-old Samantha Reynolds of Liverpool on April 12.
The family was heading to Disney World for spring break.
Gonzalez-Martinez was also charged with three counts of felony driving under the influence involving great bodily injury, not having a valid driver's license in South Carolina, and operating an uninsured vehicle, according to Corporal Bryan McDougald from the South Carolina Highway Patrol.
He was released from the hospital and taken into custody where he is being held at the Clarendon County Detention Center.
Gonzalez-Martinez got onto I-95 Exit 102 and drove about two miles before he sideswiped two cars, then collided with two vans, police said. One van was driven by William Reynolds, 39, of Liverpool; the other was driven by Lewis Griffin, 37, of Hudson.
The impact killed 14-year-old Samantha Reynolds and injured her stepmom Brenda Reynolds, steb sibling Anthony A.J. Roscoe, 18, and sibling Renee Reynolds, 14.
William Reynolds was not hurt. Two other family members, Gaige Mauro, 8, and Timothy Ungaro, 11, were released from the hospital.